Publications

1. 312026

   The Encyclopedia of DNA Elements

   The ENCODE Project Consortium (incl. Tycko J). bioRxiv

   Preprint bioRxiv PDF
2. 302026

   High-throughput measurements of protein domain functions using magnetic separation

   Thurm AR, Tycko J^#, Ludwig CH, … Bassik MC^#, Bintu L^#. Nature Protocols

   Protocol DOI
3. 292025

   Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems

   Liang Z, Maddineni A, … Tycko J, … Gottwein E. Nature Communications

   Research DOI PDF
4. 282025

   Toward optimizing diversifying base editors for high-throughput mutational scanning studies

   Schwartz CI, Abell NS, … Tycko J, Montgomery SB, Hess GT. Nucleic Acids Research

   Research DOI PDF
5. 272025

   Machine-guided dual-objective protein engineering for deimmunization and therapeutic functions

   Wolfsberg E, Paul JS, Tycko J, … Alizadeh AA, Gao XJ. Cell Systems

   Research DOI PDF
6. 262025

   An image-based CRISPR screen reveals splicing-mediated control of HP1α condensates

   Wong MMK, Zhou S, … Tycko J, … Sanulli S. bioRxiv

   Preprint bioRxiv
7. 252024

   Development of compact transcriptional effectors using high-throughput measurements in diverse contexts

   Tycko J^*, Van MV^*, Aradhana, DelRosso N, … Bintu L, Bassik MC. Nature Biotechnology

   Research DOI PDF Feature
8. 242024

   Multicenter integrated analysis of noncoding CRISPRi screens

   Yao D^*, Tycko J^*#, Oh JW^*, … Bassik MC, Reilly SK^#. Nature Methods

   ^* Co-first authors can be reported in any order

   Research DOI PDF
9. 232024

   Deciphering the impact of genomic variation on function

   The IGVF Consortium (incl. Tycko J). Nature

   Review DOI PDF
10. 222024

    Prediction and design of transcriptional repressor domains with large-scale mutational scans and deep learning

    Valbuena R^*, Nigam A^*, Tycko J, … Kundaje A, Bassik MC. bioRxiv

    Preprint bioRxiv
11. 212024

    Tunable, self-contained gene dosage control via proteolytic cleavage of CRISPR-Cas systems

    Katz N, An C, … Tycko J, … Gao XJ. bioRxiv

    Preprint bioRxiv
12. 202023

    Large-scale mapping and mutagenesis of human transcriptional effector domains

    DelRosso N, Tycko J, Suzuki P, … Bassik MC, Bintu L. Nature

    Research DOI PDF
13. 192023

    A genome-wide genetic screen uncovers determinants of human pigmentation

    Bajpai VK, Swigut T, … Tycko J, … Wysocka J. Science

    Research DOI PDF
14. 182023

    High-throughput functional characterization of combinations of transcriptional activators and repressors

    Mukund AX, Tycko J, Allen SJ, … Bassik MC, Bintu L. Cell Systems

    Research DOI PDF
15. 172023

    High-throughput discovery and characterization of viral transcriptional effectors in human cells

    Ludwig CH, Thurm AR, … Tycko J, … Glaunsinger BA, Bintu L. Cell Systems

    Research DOI PDF
16. 162023

    Direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping (CasKAS)

    Marinov GK, Kim SH, … Tycko J, … Greenleaf WJ. Genome Biology

    Research DOI PDF
17. 152022

    Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome

    Durrant MG^*, Fanton A^*, Tycko J^*, … Bhatt AS, Hsu PD. Nature Biotechnology

    ^* Co-first authors listed alphabetically

    Research DOI PDF News & Views
18. 142022

    Modeling the efficacy of CRISPR gene drive for snail immunity on schistosomiasis control

    Grewelle RE, Perez-Saez J, Tycko J, … De Leo GA. PLoS Neglected Tropical Diseases

    Research DOI PDF
19. 132022

    The sound of silence: transgene silencing in mammalian cell engineering

    Cabrera A^*, Edelstein HI^*, … Tycko J^*, … Deans TL. Cell Systems

    ^* Co-first authors listed alphabetically

    Review DOI PDF
20. 122021

    AAV vector-mediated expression of an anti-respiratory syncytial virus antibody prevents infection in mouse airways

    Tycko J, Adam VS, … Wilson JM, Limberis MP. Human Gene Therapy

    Research DOI PDF
21. 112020

    High-throughput discovery and characterization of human transcriptional effectors

    Tycko J, DelRosso N, Hess GT, … Bassik MC, Bintu L. Cell

    Research DOI PDF preLights
22. 102019

    Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

    Tycko J^*, Wainberg M^*, Marinov GK^*, … Kundaje A, Bassik MC. Nature Communications

    Research DOI PDF
23. 92019

    Identification of guide-intrinsic determinants of Cas9 specificity

    Huston NC, Tycko J, Tillotson EL, … Steinberg BE. The CRISPR Journal

    Research DOI PDF
24. 82019

    Gene drives for schistosomiasis transmission control

    Maier T, Wheeler NJ, … Tycko J, … Reinhard-Rupp J. PLoS Neglected Tropical Diseases

    Review DOI PDF
25. 72018

    Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells

    Tycko J, Barrera LA, Huston NC, … Wilson CJ, Hsu PD. Nature Communications

    Research DOI PDF
26. 62017

    Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

    Mumbach MR, Satpathy AT, … Tycko J, … Chang HY. Nature Genetics

    Research DOI PDF
27. 52017

    Advancing towards a global mammalian gene regulation model through single-cell analysis and synthetic biology

    Tycko J^*, Van MV^*, Elowitz MB, Bintu L. Current Opinion in Biomedical Engineering

    ^* Co-first authors listed alphabetically

    Review PDF
28. 42017

    Methods and applications of CRISPR-mediated base editing in eukaryotic genomes

    Hess GT^*, Tycko J^*, Yao D^*, Bassik MC. Molecular Cell

    Review DOI PDF
29. 32016

    Methods for optimizing CRISPR-Cas9 genome editing specificity

    Tycko J, Myer VE, Hsu PD. Molecular Cell

    Review DOI PDF
30. 22016

    Toolbox for exploring modular gene regulation in synthetic biology training

    Magaraci MS, Bermudez JG, … Tycko J, … Chow BY. ACS Synthetic Biology

    Research DOI PDF
31. 12013

    Lessons learned from the clinical development and market authorization of Glybera

    Bryant LM^*, … Tycko J^*, … Wilson JM. Human Gene Therapy Clinical Development

    ^* Co-first authors listed alphabetically

    Review DOI PDF

The complete and current list is available on Google Scholar